The role of immunocytochemical biomarkers in diagnostics of precancerous pathology of cervix

The last decades showed the worldwide tendency to finding consensus between diagnostics improvement and constant increase of cost medical services in conditions restricted financing. aim article was analyze diagnostic value p16 Ki-67 biomarkers precancerous diseases cervix. Data 80 patients with cervical dysplasia varying degree who received excisional treatment were analyzed. It shown that cytological study has a high sensitivity (79.17%) for diagnosis CIN 2-3, but low specificity (53.57%). immunocytochemical biomarker 2 (0.92; 95% CI: 0.76-0.98) good (0.78; 0.67-0.82), 3 both (0.93; 0.82-0.98) is high. immuno­cytochemical 0.65-0.99), insufficient (0.62; 0.54-0.64), very (0.96; 0.80-0.99) as well 0.69-0.81). combined use can significantly accuracy high-grade pathology cervix justify timely surgical intervention. Such an approach differential severe dysplasia, on one hand, may contribute decrease risk developing cancer, other it will allow avoid unnecessary operations preserve reproductive function women, reduce economic costs treatment.